Table 1.
Top 10 Substances on the
Preparation of
1999 Priority List
Toxicological Profiles
1999 Priority List
CERCLA, as amended, requires ATSDR to
Rank
Name
prepare toxicological profiles for each hazard-
1
ous substance on the CERCLA Priority List of
Hazardous Substances. These profiles summa-
2
Lead
rize the current scientific literature and interpret
3
Mercury
available toxicological and epidemiologic
4
Vinyl chloride
information to determine levels of significant
5
Benzene
human exposure regarding the substances.
6
Polychlorinated biphenyls
ATSDR also provides toxicological profiles at
7
Cadmium
the request of the Department of Defense
8
Benzo(a)pyrene
(DOD) and the Department of Energy (DOE).
9
Polyaromatic hydrocarbons
Thirty toxicological profiles were under devel-
10
Benzo(b)fluoranthene
opment as finals or drafts for public comment
during fiscal year 2000. These profiles covered
site frequency count, and thus lists the number
ATSDR has about 150
of sites at which a substance has been found in a
completed exposure pathway. The substance
toxicological profiles
found in a completed exposure pathway at the
covering about 800
most sites was lead, followed by trichloroethyl-
ene and arsenic (see Table 2).
substances.
Table 2.
Substances Found Most
Frequently at Sites with a Completed
CERCLA substances and non-CERCLA
Exposure Pathway (CEP)
substances identified by DOD and DOE (See
Appendix B for a list of toxicological profiles
Number of sites with substance in a CEP
completed in 2000). The toxicological profile
Substance
All Sites
NPL Sites
for total petroleum hydrocarbons was released
Lead
298
206
as a final profile in fiscal year 2000, thus
Trichloroethylene
277
239
completing the list of 25 substances submitted
by DOD for profile development. The final
215
147
toxicological profiles for uranium and ionizing
Tetrachloroethylene
206
167
radiation were released during fiscal year 2000;
Benzene
149
116
they were prepared at the request of DOE. The
Cadmium
148
105
following toxicological profiles were under
146
102
development as public comment drafts during
fiscal year 2000: americium, cesium, cobalt,
PCBs
130
96
iodine, and strontium. These profiles will be
1,1,1-trichloroethane
116
97
released for public comment in fiscal year 2001.
Zinc
116
75
Toxicological profiles developed in fiscal year
32 chapter 2
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