Preparation of
on October 25, 2001 (66 FR 54014). The
top substance on the 2001 Priority List of
Toxicological Profiles
CERCLA, as amended, requires ATSDR to pre-
lead and mercury (see Table 1).
pare toxicological profiles for each hazardous
Along with the publication of the revised prior-
substance on the CERCLA Priority List of
ity list in October 2001, ATSDR also published
Hazardous Substances. These profiles summa-
an updated Completed Exposure Pathway Site
rize the current scientific literature and interpret
Count Report. A completed exposure pathway
available toxicologic and epidemiologic infor-
(CEP) is an exposure pathway that links a con-
mation to determine levels of significant human
taminant source to a receptor population. The
exposure regarding the substances.
ATSDR also provides toxicological profiles at
and thus lists the number of sites at which a sub-
the request of the Department of Energy (DOE).
stance has been found in a completed exposure
Thirty-three toxicological profiles were under
pathway. The substance found in a completed
development as finals or drafts for public com-
exposure pathway at the most sites was lead,
ment during fiscal year 2001. These profiles
covered CERCLA substances and non-CER-
Table 2).
CLA substances identified by DOE (See
Table 2.
Hazardous Substances Found Most
Appendix B for a list of toxicological profiles
Frequently at Sites with a Completed
completed in fiscal year 2001). The following
Exposure Pathway (CEP)
toxicological profiles were developed at the
request of DOE and released for public com-
Number of sites with
ment during fiscal year 2001: americium,
substance in a CEP
cesium, cobalt, iodine, and strontium. These
Substance
All Sites
NPL Sites
profiles will be revised in fiscal year 2002 based
Lead
359
238
on public comments received and relevant new
studies identified. Toxicological profiles devel-
Trichloroethylene
319
271
oped in fiscal year 2001 featured a new chapter
Arsenic
267
176
entitled "Relevance to Public Health" and a new
section entitled "Toxicities Mediated Through
Tetrachloroethylene
236
190
Neuroendocrine Axis," which will be added to
Cadmium
176
123
all future profiles.
Benzene
174
128
In fiscal year 2001, 152 toxicological profiles
169
113
were available on CD-ROM. During the year,
ATSDR continued a quality control assessment
VOCs
162
118
which involved reviewing, editing, and revising
PCBs
152
104
all toxicological files on the agency's Internet
site.
Mercury
136
82
Fact sheets (called ToxFaQs), containing mate-
rial drawn from ATSDR public health state-
ments, were revised as appropriate based on the
release of new or updated toxicological profiles
34 chapter 2
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